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RESPIRATORY RESEARCH
SLEEP RESEARCH
SLEEP/RESPIRATORY RESEARCH
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About the study
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Obstructive sleep apnoea (OSA) is a common sleep breathing disorder linked with excessive daytime sleepiness and impaired cognitive performance. Untreated sleep apnoea increases the risk of motor vehicle crashes and workplace accidents. However, not all individuals with sleep apnoea experience sleepiness and performance impairments. You are invited to participate in this study as you have been using continuous positive airway pressure (CPAP) therapy, the current gold standard clinical treatment for sleep apnoea. We aim to compare the effects of sleep apnoea on daytime function and brain wave activity while you are on and off CPAP therapy.
Eligibility Requirements
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Aged 35-65 years; Confirmed diagnosis of obstructive sleep apnoea with an apnoea hypopnoea index (AHI) of at least 15 events per hour; Able to give informed consent; Fluent in English; Established users of CPAP for at least 3 months (on average 4 hours of use per night on at least 5 nights per week); Ability to perform neurobehavioural and driving simulator tasks; Current driver’s license; Willingness to comply with all study procedures and available for the duration of the study
Chief Investigator:
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Ethics Approvals:
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What's Involved
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This study will involve at least three visits to the Woolcock Institute in Glebe including: - One screening visit to confirm your eligibility to participate - Two experimental visits – each comprising of two consecutive nights and one day in the sleep lab. Each visit will be separated by at least 1 week. For one of the two experimental visits, you will be asked to continue CPAP treatment as usual (CPAP on condition). For the other, you will temporarily withdraw from treatment (CPAP off condition). These conditions will be allocated to you in a random order. Your overnight and daytime brain activity will be monitored via a non-invasive high-density electroencephalography sensor net worn on your head. You will be asked to perform performance tasks including a driving simulator task while wearing the sensor net throughout the day. NOTE: We will seek permission from your sleep physician to enrol you in this study as it involves temporary withdrawal from your treatment.
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Person Diagnosis
No
Person Diagnosis
Yes
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