About the study
The COMPANION Study: A Novel approaCh tO Manage symPtoms of nArcolepsy aNd Idiopathic hypersOmNia
Researchers at The University of Sydney and the Woolcock Institute of Medical Research are conducting a 12-week study about whether a whole food diet or a whole food ketogenic diet improve symptoms of narcolepsy and idiopathic hypersomnia.
What's involved
1. Once study physician confirms eligibility, start whole food diet run-in phase for 3 weeks (removing ultra processed foods)
2. After 3 weeks, randomisation to either continuation of the whole food diet for 9 weeks, or whole food ketogenic diet (low carbohydrate) for 9 weeks.
All COMPANION participants receive nutrition support through telehealth consultations with a registered nutritionist. There are different questionnaires, diaries etc. required to be completed throughout the study.
Visits required
Two (2) in-clinic visits - All other consultations are remote; online or phone call.
Eligibility criteria
- Formal diagnosis of narcolepsy type 1, narcolepsy type 2 or idiopathic hypersomnia by PSG/MSLT
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18 years old or over
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BMI >18.5 kg/m2
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Be willing to be involved in dietary change that may include animal protein and fat
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Be willing to monitor ketones via finger-prick and urinary dipstick
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Normal diet should be a standard diet with moderate or high carbohydrate level (above 130g carbohydrate/day)
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Additional eligibility criteria apply
Chief investigator: Dr Elizabeth Machan
Ethics approvals:
This study has been approved by the Ethics Review Committee (RPAH Zone) of the Sydney Local Health District. Any person with concerns or complaints about the conduct of this study should contact the Executive Officer on 02 9515 6766 RPA and quote protocol number X24-0044.
Find out more
Contact: Francis Cheong
Call: (02) 9805 3293
Email: francis.cheong@woolcock.org.au
